Molecular Formula | C13H16N2O2 |
Molar Mass | 232.28 |
Density | 1.168±0.06 g/cm3(Predicted) |
Boling Point | 480.0±45.0 °C(Predicted) |
pKa | 15.67±0.40(Predicted) |
In vitro study | The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells. |
biological activity | E1R is a positive allosteric modulator of the sigma-1 receptor (Sig1R PAM) with a cognitive enhancement effect. |
Animal Model: | Male ICR and Balb/c mice weighed 23-25 g |
Dosage: | 0.1, 1 and 10 mg/kg |
Administration: | Administered i.p. 60 min before the training session |
Result: | Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group. |